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KMID : 1098420090170020102
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Korean Journal of Medicinal Crop Science
2009 Volume.17 No. 2 p.102 ~ p.108
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Enhancement of Anticancer Activities of Ephedra sinica, Angelica gigas by Ultra High Pressure Extraction
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Jung Hyang-Suk
Han Jae-Gun
Ha Ji-Hye
Oh Sung-Ho
Kim Young
Kim Seung-Seop
Jeong Myeong-Hoon
Choi Geun-Pyo
Park Uk-Yeon
Lee Hyeon-Yong
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Abstract
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This study was performed to enhance anticancer activities of E. sinica, and A. gigas by ultra high pressure extraction process. The cytotoxicity of E. sinica and A. gigas on human kidney cell (HEK293) was as low as 24.94% and 25.3% in adding 1.0 of the sample extracted at 500 Mpa for 15 minute. Generally, the inhibition of cancer cell growth on A549 and MCF-7 was increased over 20% in the ultra high pressure samples, compared to the conventional extraction process. Under the extracts from ultra high pressure process showed not only the strongest anticancer activities, but also had better stability than normal extracts. It was also found that the extracts of A. gigas reduced the hypertrophy of the internal organs, such as adrenal and spleen caused stresses in several mouse models.
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KEYWORD
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Ultra high pressure extracts, Ephedra sinica, Angelica gigas, Anticancer, Cytotoxicity
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